Key events such as the advancement of IBM Watson (artificial intelligence), the Internet of Things, increasing integration of systems, robotics, 3D printing, drones and other innovations are transforming manufacturing and the supply chain to be a real-time platform that reaches beyond traditional manufacturers and into customers’ homes and places of business. At the same time, it shifts the model from a linear integrated supply chain to an eco-system of partners which interconnect to smooth product creation. What are the opportunities and challenges of this radical transformation of manufacturing? How do manufacturers keep up and stay differentiated? How do they get started? In this presentation, we will discuss the opportunities, the challenges and the tasks ahead.